Human Sera
Cayman Chemical Fexofenadine (hydrochloride), Purity: ≥98%, CAS: 153439-40-8, 100 mg
A histamine H1 receptor antagonist (Ki = 10 nM); reverses acetyl-β-methylcholine-induced contraction of isolated rat tracheal strips; inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells; reduces severity of colitis and phospho-IκB kinase activation in a mouse model of DSS-induced colitis
Cayman Chemical 2-Aminopurine (hydrochloride), Purity: ≥98%, CAS: 1428126-74-2, 50 mg
A fluorescent analog of guanosine and adenosine that is used as a site-specific probe of nucleic acid structure and dynamics, such as studies of base stacking interactions and DNA base flipping; ex/em = 320/381 nm, respectively, when adjusted to reduce interference with DNA base absorption as well as tryptophan fluorescence; inhibits PKR
Cayman Chemical T16A(inh)-A01, Purity: ≥95%, CAS: 552309-42-9, 50 mg
An aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC50 value of ~1 µM; blocks CaCC activity in vascular smooth muscle cells and relaxes mouse and human blood vessels
Cayman Chemical 1a,1b-dihomo Prostaglandin E2, Purity: ≥98%, CAS: 26198-80-1, 1 mg
A rare PUFA produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGES
Cayman Chemical 5-(2-Aminopyridyl)amide oxime, Purity: ≥98%, CAS: 468068-28-2, 50 mg
5-(2-Aminopyridyl)amide oxime is a synthetic intermediate useful for pharmaceutical synthesis
Cayman Chemical Cryptotanshinone, Purity: ≥95%, CAS: 35825-57-1, 50 mg
A natural quinoid diterpene that, at 10-20 µM, stimulates AMPK in C2C12 myotubes and activates p38 MAPK in DU145 cells; inhibits SHP2 in vitro (IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells; has a variety of anti-cancer actions
Cayman Chemical 7-hydroxycoumarinyl Arachidonate, Purity: ≥98%, CAS: 161180-11-6, 50 mg
A fluorogenic substrate for cPLA2; hydrolysis results in the release of the fluorescent compound 7-hydroxycoumarin (ex 335 nm, em 450 nm)
Cayman Chemical N-(4-acetamidophenyl)-Indomethacin amide, Purity: ≥98%, CAS: 261766-23-8, 50 mg
N-4AIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-4AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.1 and 0.625 µM, respectively.{8243,8513} It is about 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.
Cayman Chemical S-methyl-L-Thiocitrulline (hydrochloride), Purity: ≥97%, CAS: 209589-59-3, 100 mg
S-methyl-L-Thiocitrulline is a potent NOS inhibitor with selectivity toward the neuronal isoform compared to eNOS and iNOS. For human enzymes, it exhibits Ki values of 1.2, 11, and 40 nM for nNOS, eNOS, and iNOS, respectively.{1325,1293}
Cayman Chemical Levetiracetam, Purity: ≥98%, CAS: 102767-28-2, 100 mg
An antiepileptic agent; binds to the synaptic vesicle protein SV2A (IC50 = 1.99 μM); suppresses seizures in fully kindled rats
Cayman Chemical N-Desethylamiodarone (hydrochloride), Purity: ≥95%, CAS: 96027-74-6, 50 mg
the major CYP3A4 metabolite of amiodarone; used as an analytical reference standard for monitoring clinical efficacy of amiodarone in plasma samples
Cayman Chemical Heptadecanoyl Ethanolamide, Purity: ≥98%, CAS: 53832-59-0, 50 mg
A synthetic analog of PEA which incorporates an odd-numbered (17-carbon) fatty acid achain; potentiates the Ca2+ influx in response to AEA several fold in cells expressing human recombinant VR1
Cayman Chemical Eicosapentaenoic Acid methyl ester, Purity: ≥98%, CAS: 2734-47-6, 50 mg
An esterified form of EPA; has been used as a reference standard in the quantification of fatty acids in microalgal and fish oils
Cayman Chemical Clinafloxacin (hydrochloride), Purity: ≥95%, CAS: 105956-99-8, 100 mg
A fluoroquinolone antibiotic that displays broad spectrum antibacterial activity by inhibiting the bacterial regulatory enzyme DNA gyrase (IC50 = 0.92 µg/ml) as well as topoisomerase IV (IC50 = 1.62 µg/ml)
Cayman Chemical Pterostilbene, Purity: ≥98%, CAS: 537-42-8, 100 mg
A stilbene with diverse biological activities; reduces acifluorfen-induced photooxidative leakage in C. sativus cotyledon disks at 30 µg/ml; inhibits TPA-induced invasion and migration of HepG2 cells at 25 and 50 µM; inhibits production of NO and PGE2 in LPS-stimulated RAW 264.7 macrophages at 10 and 20 µM; activates PPARα in H4IIEC3 cells at 100 and 300 µM; decreases plasma glucose and LDL levels and increases plasma HDL levels in a hamster model of high-fat diet-induced hypercholesterolemia at 25 ppm in the diet